> Horror! To me, the acceptable slowdown is exactly zero.
If you care about single % of performance, why are you using Python in the first place? You're likely losing 100x to more performant languages already.
Because I care about elegance of code and developer productivity even more. And there is no other language which comes close to Python in these regards.
Elegance of code is subjective and developer productivity is more a trait of a developer than a language (which means it is inherently subjective, e.g. in my case Python is among the languages I was least productive in; I find myself much more productive in Scala, Kotlin, Rust and even R for statistics).
If you care about single % of performance, why are you using Python in the first place? You're likely losing 100x to more performant languages already.