Oh, awesome, thank you!. I never thought to use ZeroMQ, but that would work perfectly. Ironically, it doesn't seem like DotCloud supports these sorts of architectures very well yet, any plans to fix that? ;)
Absolutely - our job is to make developers happy and productive. Whenever we find a sweet tool that makes our lives easier, we're practically tripping over ourselves to share it with you
Our network team is working on some major goodies which should make you happy. Personally they bring tears to my eyes :)
In the meantime, my recommendation is to start with http. If you keep the RPC semantics simple, you can easily migrate to a different transport later. And you'll need HTTP to authenticate and encrypt at the boundaries anyway.