I would really encourage you to review the study again. For example, the authors themselves acknowledged a lot of legitimate reader concerns with the inclusion of this statement:
"These observational studies have 4 important limitations. First, current anticholinergic use was ascertained at study entry and periodically during follow-up only by conducting a medication inventory. Second, these studies lacked information about the dose and duration of anticholinergic use. Third, these studies had short follow-up periods. This last point is important because the pathophysiological changes in the brains of patients with AD require several years to occur. Finally, these studies did not take into account that certain anticholinergics are used to manage insomnia and depression, prodromal conditions that can be seen in early but undiagnosed dementia, leading to protopathic bias."
I had other concerns as well, and these items alone are a pretty big deal. Like I said above, the _quality_ of the establishment of a "link" is really leaving much to be desired here. This is barely even legitimate science, where any kind of causality is concerned.
"These observational studies have 4 important limitations. First, current anticholinergic use was ascertained at study entry and periodically during follow-up only by conducting a medication inventory. Second, these studies lacked information about the dose and duration of anticholinergic use. Third, these studies had short follow-up periods. This last point is important because the pathophysiological changes in the brains of patients with AD require several years to occur. Finally, these studies did not take into account that certain anticholinergics are used to manage insomnia and depression, prodromal conditions that can be seen in early but undiagnosed dementia, leading to protopathic bias."
I had other concerns as well, and these items alone are a pretty big deal. Like I said above, the _quality_ of the establishment of a "link" is really leaving much to be desired here. This is barely even legitimate science, where any kind of causality is concerned.
https://jamanetwork.com/journals/jamainternalmedicine/fullar...